n/a
Article Publish Status: FREE
Abstract Title:

Tanshinone IIA attenuates cerebral aneurysm formation by inhibiting the NF‑κB‑mediated inflammatory response.

Abstract Source:

Mol Med Rep. 2019 Aug ;20(2):1621-1628. Epub 2019 Jun 20. PMID: 31257487

Abstract Author(s):

Jun Ma, Daorong Hou, Zhiqing Wei, Jianguo Zhu, Hua Lu, Zheng Li, Xiefeng Wang, Yingbin Li, Guanqun Qiao, Ning Liu

Article Affiliation:

Jun Ma

Abstract:

The inflammatory response plays a vital role in cerebral aneurysm (CA) formation and progression. Tanshinone IIA (Tan IIA) is one of the major active components of Chinese medicine Danshen (Salvia miltiorrhiza Bunge) and is widely used for the treatment of cardiovascular diseases, due to its anti‑inflammatory effects. The aim of the present study was to investigate whether Tan IIA can attenuate CA formation in rat models, and determine its underlying mechanisms. CAs were induced in rats surgically and through high‑salt diet treatments. The Tan IIA‑treated group displayed relatively mild symptoms, as compared with the control group. Tan IIA treatment reduced macrophage infiltration and nuclearfactor (NF)‑κB activation in aneurysmal walls. Next, lipopolysaccharide (LPS)‑stimulated RAW 264.7 murine macrophage cells were used to examine the anti‑inflammatory effects of Tan IIA on macrophages. It was found that Tan IIA reversed LPS‑induced differentiation of RAW 264.7 cells and suppressed NF‑κB pathway activation. In conclusion, these findings demonstrated that Tan IIA can suppress CA formation by inhibiting inflammatory responses in macrophages.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.