Abstract Title:

Targeting gut microbiota with dietary components on cancer: Effects and potential mechanisms of action.

Abstract Source:

Crit Rev Food Sci Nutr. 2019 Jan 11:1-13. Epub 2019 Jan 11. PMID: 30632784

Abstract Author(s):

Jun Tao, Sha Li, Ren-You Gan, Cai-Ning Zhao, Xiao Meng, Hua-Bin Li

Article Affiliation:

Jun Tao


Cancers are common chronic diseases worldwide and cause severe health burdens. There have been ongoing debates on the role of gut microbiota in the prevention and management of cancers, thus, it is worthwhile to pay high attention to the impacts of gut microbiota on several cancers, such as colon, liver, and breast cancers. In addition, it has been reported that gut microbiota may also affect the efficacy of cancer chemotherapy and immunotherapy. Among all the factors that influence gut microbiota, diet is the most influential and modifiable. The prebiotics, dietary fibers, short-chain fatty acids, and other bioactive compounds are all important dietary components to assist the growth of beneficial microbiota in the gut, which can protect against cancers and promote human health. Their beneficial effects can be due to the fermentation of dietary fibers, the metabolism of phytochemicals, the synthesis of estrogens, and interactions with chemotherapies and immunotherapies. In order to provide updated information of the relationships among dietary components, gut microbiota, and cancer, in this review, we summarize the reciprocal interactions between dietary components and gut microbiota, and highlight the impacts of dietary components on several common cancers by targeting gut microbiota, with the potential mechanisms of actions also intensively discussed. As a result, this review can be very helpful for healthy people as well as cancer patients to prevent or manage cancers via dietary factor-mediated regulation of gut microbiota.

Study Type : Review

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