Abstract Title:

Pure delta-9-tetrahydrocannabinol and its combination with cannabidiol in treatment-resistant Tourette syndrome: A case report.

Abstract Source:

Int J Psychiatry Med. 2018 Jul 30:91217418791455. Epub 2018 Jul 30. PMID: 30058466

Abstract Author(s):

Eva-Maria Pichler, Wolfram Kawohl, Erich Seifritz, Patrik Roser

Article Affiliation:

Eva-Maria Pichler


Objectives Anecdotal reports and preliminary studies suggest a therapeutic potential of cannabis in Tourette syndrome. We report the case of a female patient suffering from treatment-resistant Tourette syndrome. Methods Guideline-directed antipsychotic treatment with risperidone and aripiprazole as well as pure delta-9-tetrahydrocannabinol had no significant effect on Tourette syndrome symptomatology. Results Following administration of a daily dosage of 10 mg delta-9-tetrahydrocannabinol combined with 20 mg cannabidiol (CBD), the patient showed a rapid and highly significant improvement in the Yale Global Tic Severity Scale. Conclusions It can be speculated whether the beneficial effects may rely on the pharmacological properties of cannabidiol.

Study Type : Human: Case Report

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