Therapeutic effect of Ecklonia cava extract in letrozole-induced polycystic ovary syndrome. - GreenMedInfo Summary
Therapeutic Effect ofExtract in Letrozole-Induced Polycystic Ovary Syndrome Rats.
Front Pharmacol. 2018 ;9:1325. Epub 2018 Nov 19. PMID: 30524282
Polycystic ovary syndrome (PCOS) is an endocrinal disorder that afflicts mainly women of childbearing age. The symptoms of PCOS are irregular menstrual cycles, weight gain, subfertility and infertility. However, because the etiology is unclear, management and treatment methods for PCOS are not well established. Recently, natural substances have been used for PCOS therapy.() is a well-known natural substance that attenuates the effects of inflammation, allergies, and cancer. In this study, we investigated the effects ofextract in rats with PCOS. When rats with letrozole-induced PCOS were exposed to theextract, the regular estrus cycle was restored, similar to that in placebo rats. Hormone levels, including the levels of testosterone, estrogen, luteinizing hormone (LH), follicle stimulating hormone (FSH), and anti-Müllerian hormone (AMH), were restored to their normal states. Histological analysis revealed that the polycystic ovary symptoms were significantly decreased in the-treated rats and were comparable to those of normal ovaries. At the transcriptional and translational levels,, andlevels were markedly increased in the-treated rats with PCOS compared with the rats with letrozole-induced PCOS. These results suggest that theextract inhibits the symptoms of PCOS by restoring imbalanced hormonal levels and irregular ovarian cycles in letrozole-induced female rats.