Therapeutic efficacy ofcoated iron oxide nanoparticles in A549 lung cancer cell line.
Nanomedicine (Lond). 2019 09 ;14(17):2355-2371. Epub 2019 Aug 15. PMID: 31414606
Present work was undertaken to fabricate iron oxide nanoparticles (IONPs) using a green approach for increased therapeutic efficacy.Two types of IONPs were synthesized, one without any coating (IONP) and other coated with(Amla) fruit extract (IONP). Both the IONPs were characterized using different techniques and therapeutic efficacy was evaluated in A549 human lung cancer cell line.IONPwere smaller in size with better dispersibility compared with IONP. They induced increased reactive oxygen species production, higher DNA damage and apoptosis, which resulted in increased toxicity to cancer cells in comparison to IONP.Higher uptake of IONPand active components coating the surface, may be responsible for the increased therapeutic efficacy in cancer cells.