n/a
Abstract Title:

Therapeutic potential of biochanin-A against isoproterenol -induced myocardial infarction in rats.

Abstract Source:

Cardiovasc Hematol Agents Med Chem. 2020 Feb 5. Epub 2020 Feb 5. PMID: 32026788

Abstract Author(s):

Sangeethadevi Govindasami, Veera Venkata Sathibabu Uddandrao, Nivedha Raveendran, Vadivukkarasi Sasikumar

Article Affiliation:

Sangeethadevi Govindasami

Abstract:

BACKGROUND: This study determined the effect of Biochanin A (BCA) on isoproterenol (ISO) induced myocardial infarction (MI) in male Wistar rats.

METHODS: Animals (Weighing 150-180 g) were divided into four groups, with six animals in each group and pretreated with BCA (10mg/kg body weight [BW] andɑ-tocopherol (60mg/kg BW for 30 days; and ISO (20mg/kg BW) was administrated subcutaneously on the day 31 and 32.

RESULTS: ISO-induced MI rats demonstrated the significant elevation of serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, lactate dehydrogenase, creatine kinase-MB and cardiac troponin; however, concomitant pretreatment with BCA protected the rats from cardiotoxicity caused by ISO. Activities of antioxidant enzymes, such as superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase and glutathione reductase had significantly reduced in the heart with ISO-induced MI. Pretreatment with BCA produced a marked reversal of these antioxidant enzymes related to MI¬¬-induced by ISO.

CONCLUSION: In conclusion, this study suggested that BCA exerts cardioprotective effects through modulating lipid peroxidation, enhancing antioxidants, and detoxifying enzyme systems.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.