Article Publish Status: FREE
Abstract Title:

Therapeutic Potential offor Depressive Disorder.

Abstract Source:

Int J Mol Sci. 2019 Dec 25 ;21(1). Epub 2019 Dec 25. PMID: 31881712

Abstract Author(s):

Pit Shan Chong, Man-Lung Fung, Kah Hui Wong, Lee Wei Lim

Article Affiliation:

Pit Shan Chong


Depression is a common and severe neuropsychiatric disorder that is one of the leading causes of global disease burden. Although various anti-depressants are currently available, their efficacies are barely adequate and many have side effects.also known as Lion's mane mushroom, has been shown to have various health benefits, including antioxidative, antidiabetic, anticancer, anti-inflammatory, antimicrobial, antihyperglycemic, and hypolipidemic effects. It has been used to treat cognitive impairment, Parkinson's disease, and Alzheimer's disease. Bioactive compounds extracted from the mycelia and fruiting bodies ofhave been found to promote the expression of neurotrophic factors that are associated with cell proliferation such as nerve growth factors. Although antidepressant effects ofhave not been validated and compared to the conventional antidepressants, based on the neurotrophic and neurogenic pathophysiology of depression,may be a potential alternative medicine for the treatment of depression. This article critically reviews the current literature on the potential benefits ofas a treatment for depressive disorder as well as its mechanisms underlying the antidepressant-like activities.

Study Type : Review

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Sayer Ji
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