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Article Publish Status: FREE
Abstract Title:

Therapeutic Potential of the Natural Compound S-Adenosylmethionine as a Chemoprotective Synergistic Agent in Breast, and Head and Neck Cancer Treatment: Current Status of Research.

Abstract Source:

Int J Mol Sci. 2020 Nov 13 ;21(22). Epub 2020 Nov 13. PMID: 33202711

Abstract Author(s):

Laura Mosca, Francesca Vitiello, Alessandra Coppola, Luigi Borzacchiello, Concetta Paola Ilisso, Martina Pagano, Michele Caraglia, Giovanna Cacciapuoti, Marina Porcelli

Article Affiliation:

Laura Mosca

Abstract:

The present review summarizes the most recent studies focusing on the synergistic antitumor effect of the physiological methyl donor S-adenosylmethionine (AdoMet) in association with the main drugs used against breast cancer and head and neck squamous cell carcinoma (HNSCC), two highly aggressive and metastatic malignancies. In these two tumors the chemotherapy approach is recommended as the first choice despite the numerous side effects and recurrence of metastasis, so better tolerated treatments are needed to overcome this problem. In this regard, combination therapy with natural compounds, such as AdoMet, a molecule with pleiotropic effects on multiple cellular processes, is emerging as a suitable strategy to achieve synergistic anticancer efficacy. In this context, the analysis of studies conducted in the literature highlighted AdoMet as one of the most effective and promising chemosensitizing agents to be taken into consideration for inclusion in emerging antitumor therapeutic modalities such as nanotechnologies.

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Sayer Ji
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