Abstract Title:

Increased levels of polychlorobiphenyls in Italian women with endometriosis.

Abstract Source:

Chemosphere. 2006 May;63(8):1361-7. Epub 2005 Nov 11. PMID: 16289286

Abstract Author(s):

Maria Grazia Porpora, Anna Maria Ingelido, Alessandro di Domenico, Annamaria Ferro, Manuela Crobu, Debora Pallante, Massimo Cardelli, Ermelando V Cosmi, Elena De Felip

Article Affiliation:

Department of Gynecological Sciences, Perinatology and Child Health, University La Sapienza, 00161 Rome, Italy.

Abstract:

Endometriosis has been hypothesised to be linked to persistent and toxic organochlorinated chemicals. Dioxins and dioxin-like compounds have in particular been associated with the disease, mainly on the basis of experimental studies. Data in women are conflicting. A case-control study on 80 Italian nulliparous women of reproductive age was carried out to assess whether there is a correlation between the presence of endometriosis and blood levels of polychlorobiphenyls (PCBs), a family of ubiquitary environmental pollutants which comprises congeners with dioxin-like activity. Higher levels of PCBs were found in women with endometriosis. A mean cumulative value of 410 ng g(-1), lipid base, was found in cases versus the value of 250 ng g(-1) observed in the control group (odds ratio for upper tertile 4.0, CI 95% 1.3-13; p = 0.0003). PCB increase involved both dioxin-like (PCBs 105, 118, 156, and 167) and non-dioxin-like congeners (PCBs 101, 138, 153, 170, 180).

Study Type : Human Study

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