The correlation between PMexposure and hypertensive disorders in pregnancy: A Meta-analysis.
Sci Total Environ. 2019 Nov 2 ;703:134985. Epub 2019 Nov 2. PMID: 31731170
OBJECTIVE: To find the correlation between exposure to PM(fine particulate matter) and hypertensive disorders in pregnancy (HDP), and provide medical evidence for decreasing the incidence of hypertensive disorders in pregnancy.
METHOD: A combination of computer and manual retrieval was used to search for keywords in PubMed (385 records), Cochrane Library (20 records), Web of Science (419 records) and Embase (325 records). Finally, ten epidemiological articles were considered in this meta-analysis. Stata 13.0 was used to examine the heterogeneity among the studies and to calculate the combined effect value (OR, odds ratio) by selecting the corresponding models. Sensitivity analysis and publication bias test were also performed.
RESULTS: Meta-analysis indicated that there was an association between PMexposure (per 10 µg/mincrease) and hypertensive disorders in pregnancy (OR = 1.52, 95% CI: 1.24-1.87). Exposure to PM(per 10 µg/mincrease) enhanced the risk of pre-eclampsia (OR = 1.31, 95% CI: 1.07-1.61), but there was no evidence relating exposure to PMto gestational hypertension (OR = 1.35, 95% CI: 0.98-1.87).
CONCLUSION: There is a significant link between exposure to PMand hypertensive disorders in pregnancy. The first and the third trimester were more susceptible to PMexposure. It is recommended to further strengthen protective measures against PMduring pregnancy.