Abstract Title:


Abstract Source:

J Neurophysiol. 2018 Aug 22. Epub 2018 Aug 22. PMID: 30133383

Abstract Author(s):

Corinne El Khoueiry, Daniela Moretti, Rémy Renom, Francesca Camera, Rosa Orlacchio, André Garenne, Florence Poulletier de Gannes, Emmanuelle Poque-Haro, Isabelle Lagroye, Bernard Veyret, Noëlle Lewis

Article Affiliation:

Corinne El Khoueiry


So far, the only identified biological effects of radiofrequency fields (RF) are known to be caused by heating but the issue of potential nonthermal biological effects, especially on the central nervous system (CNS), remains open. We previously reported a decrease in the firing and bursting rates of neuronal cultures exposed to a Global System for Mobile (GSM) RF field at 1800 MHz for 3 min (Moretti et al. 2013). The aim of the present work was to assess the dose-response relationship for this effect, and also identify a potential differential response elicited by pulse-modulated GSM and continuous-wave (CW) RF fields. Spontaneous bursting activity of neuronal cultures from rat embryonic cortices was recorded using 60-electrode Multi Electrode Arrays (MEAs). At 17-28 days in vitro, the neuronal cultures were subjected to 15-min RF exposures, at SARs (Specific Absorption Rates) ranging from 0.01 to 9.2 W/kg. Both GSM and CW signals elicited a clear decrease in bursting rate during the RF exposure phase. This effect became more marked with increasing SAR and lasted even beyond the end of exposure for the highest SAR levels. Moreover, the amplitude of the effect was greater with the GSM signal. Altogether, our experimental findings provide evidence for dose-dependent effects of RF signals on the bursting rate of neuronal cultures and suggest that part of the mechanism is nonthermal.

Study Type : In Vitro Study
Additional Links
Adverse Pharmacological Actions : Neurotoxic : CK(2424) : AC(562)

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