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Article Publish Status: FREE
Abstract Title:

Astragaloside IV ameliorates renal injury in db/db mice.

Abstract Source:

Sci Rep. 2016 Sep 2 ;6:32545. Epub 2016 Sep 2. PMID: 27585918

Abstract Author(s):

Huili Sun, Wenjing Wang, Pengxun Han, Mumin Shao, Gaofeng Song, Heng Du, Tiegang Yi, Shunmin Li

Article Affiliation:

Huili Sun

Abstract:

Diabetic nephropathy is a lethal complication of diabetes mellitus and a major type of chronic kidney disease. Dysregulation of the Akt pathway and its downstream cascades, including mTOR, NFκB, and Erk1/2, play a critical role in the development of diabetic nephropathy. Astragaloside IV is a major component of Huangqi and exerts renal protection in a mouse model of type 1 diabetes. The current study was undertaken to investigate the protective effects of diet supplementation of AS-IVon renal injury in db/db mice, a type 2 diabetic mouse model. Results showed that administration of AS-IV reduced albuminuria, ameliorated changes in the glomerular and tubular pathology, and decreased urinary NAG, NGAL, and TGF-β1 in db/db mice. AS-IV also attenuated the diabetes-related activation of Akt/mTOR, NFκB, and Erk1/2 signaling pathways without causing any detectable hepatotoxicity. Collectively, these findings showed AS-IV to be beneficial to type 2 diabetic nephropathy, which might be associated with the inhibition of Akt/mTOR, NFκB and Erk1/2 signaling pathways.

Study Type : Animal Study

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