Article Publish Status: FREE
Abstract Title:

Cardiorespiratory Fitness Attenuates the Influence of Amyloid on Cognition.

Abstract Source:

J Int Neuropsychol Soc. 2015 Nov ;21(10):841-50. PMID: 26581795

Abstract Author(s):

Stephanie A Schultz, Elizabeth A Boots, Rodrigo P Almeida, Jennifer M Oh, Jean Einerson, Claudia E Korcarz, Dorothy F Edwards, Rebecca L Koscik, Maritza N Dowling, Catherine L Gallagher, Barbara B Bendlin, Bradley T Christian, Henrik Zetterberg, Kaj Blennow, Cynthia M Carlsson, Sanjay Asthana, Bruce P Hermann, Mark A Sager, Sterling C Johnson, James H Stein, Ozioma C Okonkwo

Article Affiliation:

Stephanie A Schultz

Abstract:

The aim of this study was to examine cross-sectionally whether higher cardiorespiratory fitness (CRF) might favorably modify amyloid-β (Aβ)-related decrements in cognition in a cohort of late-middle-aged adults at risk for Alzheimer's disease (AD). Sixty-nine enrollees in the Wisconsin Registry for Alzheimer's Prevention participated in this study. They completed a comprehensive neuropsychological exam, underwent 11C PittsburghCompound B (PiB)-PET imaging, and performed a graded treadmill exercise test to volitional exhaustion. Peak oxygen consumption (VO2peak) during the exercise test was used as the index of CRF. Forty-five participants also underwent lumbar puncture for collection of cerebrospinal fluid (CSF) samples,from which Aβ42 was immunoassayed. Covariate-adjusted regression analyses were used to test whether the association between Aβ and cognition was modified by CRF. There were significant VO2peak*PiB-PET interactions for Immediate Memory (p=.041) and Verbal Learning&Memory (p=.025). There were also significant VO2peak*CSF Aβ42 interactions for Immediate Memory (p<.001) and Verbal Learning&Memory (p<.001). Specifically, in the context of high Aβ burden, that is, increased PiB-PET binding or reduced CSF Aβ42, individuals with higher CRF exhibited significantly better cognition compared with individuals with lower CRF. In a late-middle-aged, at-risk cohort, higher CRF is associated with a diminution of Aβ-related effects on cognition. These findings suggest that exercise might play an important role in the prevention of AD.

Study Type : Human Study
Additional Links
Therapeutic Actions : Exercise : CK(2795) : AC(411)

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