Abstract Title:

MicroRNA-1469, a p53-responsive microRNA promotes Genistein induced apoptosis by targeting Mcl1 in human laryngeal cancer cells.

Abstract Source:

Biomed Pharmacother. 2018 Oct ;106:665-671. Epub 2018 Jul 11. PMID: 29990856

Abstract Author(s):

Chang-Hong Ma, Yi-Xiang Zhang, Ling-Hao Tang, Xue-Jun Yang, Wan-Ming Cui, Chuan-Chun Han, Wen-Yue Ji

Article Affiliation:

Chang-Hong Ma


Genistein, a plant isoflavone, is reported to have therapeutic potentials in multiple cancers, However, the molecular mechanism underlying promoting cell apoptosis in laryngeal cancer remains unclear. In this study, we report that miR-1469 was induced by genistein in laryngeal cancer. Elevated miR-1469 promoted cell apoptosis and inhibited Mcl1 expression. In addition, we also observed that tumor suppressor p53 was increased under genistein treatment. Elevation of p53 promoted miR-1469 expression, leading to miR-1469 increase and Mcl1 decrease. Therefore, our findings suggest that genistein can suppress laryngeal cancer cell survival through p53 -miR-1469-Mcl1pathway.

Study Type : In Vitro Study

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