Article Publish Status: FREE
Abstract Title:

Tanshinone IIA improves functional recovery in spinal cord injury-induced lower urinary tract dysfunction.

Abstract Source:

Neural Regen Res. 2017 Feb ;12(2):267-275. PMID: 28400810

Abstract Author(s):

Yong-Dong Yang, Xing Yu, Xiu-Mei Wang, Xiao-Hong Mu, Feng He

Article Affiliation:

Yong-Dong Yang


Tanshinone IIA, extracted fromBunge, exerts neuroprotective effects through its anti-inflammatory, anti-oxidative and anti-apoptotic properties. This study intravenously injected tanshinone IIA 20 mg/kg into rat models of spinal cord injury for 7 consecutive days. Results showed that tanshinone IIA could reduce the inflammation, edema as well as compensatory thickening of the bladder tissue, improve urodynamic parameters, attenuate secondary injury, and promote spinal cord regeneration. The number of hypertrophic and apoptotic dorsal root ganglion (L-S) cells was less after treatment with tanshinone IIA. The effects of tanshinone IIA were similar to intravenous injection of 30 mg/kg methylprednisolone. These findings suggested that tanshinone IIA improved functional recovery after spinal cord injury-induced lower urinary tract dysfunction by remodeling the spinal pathway involved in lower urinary tract control.

Study Type : Animal Study

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Sayer Ji
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