n/a
Abstract Title:

Hepatoprotective and anti-inflammatory effects of a standardized pomegranate () fruit extract in high fat diet-induced obese C57BL/6 mice.

Abstract Source:

Int J Food Sci Nutr. 2020 Nov 18:1-12. Epub 2020 Nov 18. PMID: 33203257

Abstract Author(s):

Marisa Pfohl, Nicholas A DaSilva, Emily Marques, Juliana Agudelo, Chang Liu, Michael Goedken, Angela L Slitt, Navindra P Seeram, Hang Ma

Article Affiliation:

Marisa Pfohl

Abstract:

Diets rich in fats are linked to elevated systemic inflammation, which augments the progression of inflammatory-related disorders including non-alcoholic fatty liver disease (NAFLD) and neurodegenerative diseases. A phenolic-enriched pomegranate fruit extract (PE) was investigated for its hepatoprotective and anti-inflammatory effects in male C57BL/6 mice fed either a high-fat diet or a standard rodent diet with or without 1% of PE for 12 weeks. Mouse livers and hippocampi were evaluated for the expression of genes associated with NAFLD and inflammation by multiplexed gene analysis. PE alleviated diet-induced fatty liver and suppressed hepatic lipid regulating genes including,,and. In addition, PE suppressed gene expression of pro-inflammatory cytokines including,,,,andin the hippocampi. Our findings support the protective effects of PE against high-fat diet-induced hepatic and neurological disease.

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.