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Abstract Title:

Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling.

Abstract Source:

Mol Cell Proteomics. 2019 03 ;18(3):520-533. Epub 2019 Jan 7. PMID: 30617157

Abstract Author(s):

Qi Zhao, Fang Liu, Yan Cheng, Xue-Rong Xiao, Dan-Dan Hu, Ying-Mei Tang, Wei-Min Bao, Jin-Hui Yang, Tao Jiang, Jia-Peng Hu, Frank J Gonzalez, Fei Li

Article Affiliation:

Qi Zhao

Abstract:

Celastrol, derived from the roots of the, shows a striking effect on obesity. In the present study, the role of celastrol in cholestasis was investigated using metabolomics and transcriptomics. Celastrol treatment significantly alleviated cholestatic liver injury in mice induced byα-naphthyl isothiocyanate (ANIT) and thioacetamide (TAA). Celastrol was found to activate sirtuin 1 (SIRT1), increase farnesoid X receptor (FXR) signaling and inhibit nuclear factor-kappa B and P53 signaling. The protective role of celastrol in cholestatic liver injury was diminished in mice on co-administration of SIRT1 inhibitors. Further, the effects of celastrol on cholestatic liver injury were dramatically decreased in-null mice, suggesting that the SIRT1-FXR signaling pathway mediates the protective effects of celastrol. These observations demonstrated a novel role for celastrol in protecting against cholestatic liver injury through modulation of the SIRT1 and FXR.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Hepatoprotective : CK(3182) : AC(1418)

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