Article Publish Status: FREE
Abstract Title:

Antigenotoxic Properties ofagainst Hydrogen Peroxide in Human Peripheral Blood Cells.

Abstract Source:

Oxid Med Cell Longev. 2017 ;2017:8759764. Epub 2017 Feb 21. PMID: 28316757

Abstract Author(s):

Lada Živković, Sunčica Borozan, Andrea Čabarkapa, Dijana Topalović, Ummi Ciptasari, Vladan Bajić, Biljana Spremo-Potparević

Article Affiliation:

Lada Živković


The ability ofmushroom in its dried and powdered mycelial form was evaluated for its antigenotoxic properties for the first time. Antigenotoxic effects in human peripheral blood cells against HO-induced DNA damage were examined in pretreatment and posttreatment protocol by comet assay. The results showed better antigenotoxic properties ofon the interventional level, respectively, after treatment.in concentration of 250 g/mL after treatment was most efficient in regard to its action against DNA damage. The evaluation of repair kinetics showed decrease in HOinduced DNA damage 15 min after the application of, reaching the maximum potency after 30 min. Analysis of antioxidant properties ofrevealed strongOH scavenging properties and moderate reducing power, while its DPPH scavenging ability was weak. In regard to our findings, we can conclude that our preliminary results demonstrated antigenotoxic properties ofand its strongOH scavenging ability. Mechanisms underlying its properties should be further evaluated in in vivo studies.

Study Type : Human In Vitro

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