Myricetin attenuates neurodegeneration and cognitive impairment in Parkinsonism.
Front Biosci (Elite Ed). 2018 Jun 1 ;10:481-494. Epub 2018 Jun 1. PMID: 29772521
Parkinson's disease (PD) is a progressive neurodegenerative disease due to dopaminergic neuron degeneration. It mostly affects the aged population, leads to memory decline and loss of motor coordination. The present study investigates the neuroprotective role of myricetin a flavonol isolated from the brown seaweedin rotenone inducedmodel of PD. Rotenone administration led to dopaminergic neuronal degeneration, dopamine depletion, impaired muscular coordination, gait disturbances, memory decline oxidative stress and apoptosis. Ingestion of myricetin bysignificantly prevented rotenone induced neuronal degeneration. These results confirm that myricetin exerts neuroprotective effect in experimental PD.