Chronic Administration of Ellagic Acid Improved the Cognition in Male Middle-aged Overweight.
Appl Physiol Nutr Metab. 2017 Oct 20. Epub 2017 Oct 20. PMID: 29053933
This study aims to investigate whether ellagic acid has beneficial effects on cognitive deficits in middle-aged overweight individuals and the possible mechanism. A total of 150 middle-aged male participants, including 76 normal weight and 74 overweight, aged between 45 to 55 years were recruited for this study. Both normal weight and overweight participants were administered either 50 mg ellagic acid or placebo cellulose daily for 12 weeks. Blood lipids, peripheral brain-derived neurotrophic factor (BDNF) and saliva cortisol were assessed on the last day of the procedure to investigate the effects induced by ellagic acid. The results revealed that ellagic acid treatment improved the levels of blood lipid metabolism with a 4.7% decline in total cholesterol, 7.3% decline in triglycerides, 26.5% increase in high-density lipoprotein and 6.5% decline in low-density lipoprotein. Additionally, ellagic acid increased 21.2% of plasma BDNF in the overweight group and showed no effects on normal weight participants. Moreover, the increased saliva cortisol level in overweight individuals was inhibited to 22.7% by a 12-week ellagic acid treatment. Also, compared with placebo, overweight individuals who consumed ellagic acid showed enhanced cognitive function as measured by the Wechsler Adult Intelligence Scale-Revised and the Montreal cognitive assessment. To the best of our knowledge, this is the first report showing that ellagic acid prevents cognitive deficits through normalization of lipid metabolism, increase in plasma BDNF level and reduction of saliva cortisol concentration. These results indicate that ellagic acid has a potential to restore cognitive performance related to mild age-related declines.