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Abstract Title:

Anti-hypercholesterolemic influence of the spice cardamom (Elettaria cardamomum) in experimental rats.

Abstract Source:

J Sci Food Agric. 2016 Nov 26. Epub 2016 Nov 26. PMID: 27888503

Abstract Author(s):

Shamarao Nagashree, Kottangada K Archana, Pullabhatla Srinivas, Krishnapura Srinivasan, Halagur B Sowbhagya

Article Affiliation:

Shamarao Nagashree

Abstract:

BACKGROUND: Cardamom (Elettaria cardamomum) is an aromatic seed spice grown extensively in India and used as a flavoring in sweets. The anti-hypercholesterolemic effect of cardamom was evaluated in Wistar rats by inducing hypercholesterolemia with a high cholesterol diet for 8 weeks. Dietary interventions were made with (a) Cardamom powder (50 g.kg(-1) ), (b) Cardamom oil (3 g.kg(-1) ) (equivalent to 50 g.kg(-1) cardamom), and (c) de-oiled cardamom powder (50 g.kg(-1) ).

RESULTS: Significant reduction in the blood total cholesterol (31%) and LDL cholesterol (44%) was observed by oral administration of cardamom oil in hypercholesterolemic rats accompanied by a marked decrease in serum triglycerides by 42%. Cholesterol content of cardiac muscle was beneficially lowered by 39% with administration of cardamom oil in hypercholesterolemic rats. Liver triglycerides were reduced by 33%. Incorporation of cardamom oil/powder in diet did not alter the feed consumption in rats. Compromised activities of hepatic antioxidant enzymes under hypercholesterolemic situation were generally countered by dietary cardamom. Treatment with de-oiled cardamom as well as cardamom oil countered the diminished activity of catalase in hypercholesterolemic animals. Cardamom also enhanced the activity of heart superoxide dismutase in hypercholesterolemic situation. Ascorbic acid concentration in circulation was significantly increased by dietary cardamom or its fractions in hypercholesterolemic situation.

CONCLUSIONS: This animal study has thus established the potential of cardamom oil in restoring the alteration in lipid homeostasis in conditions of hypercholesterolemia. Significant reduction of atherogenicity index by dietary intervention with cardamom powder and cardamom oil indicates the potential cardio protective effect of cardamom.

Study Type : Animal Study

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Sayer Ji
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