Inhibitory and preventive effects ofFB-T9 on dental caries in rats.
J Oral Microbiol. 2020 ;12(1):1703883. Epub 2019 Dec 25. PMID: 32002130
is recognized as the main cause of dental caries, and the formation of a plaque biofilm is required for caries development. This study aimed to determine the inhibitory effect ofFB-T9 onbiofilm formationand on the prevention and treatment of dental caries in rats. Duringexperiments, FB-T9 exhibited good bacteriostatic ability in a plate competition assay. This strain also significantly reduced the biomass and viability ofbiofilms and induced structural damage during the early (6 h), middle (12 h) and late (24 h) stages of biofilm formation. In a 70-dayexperiment, FB-T9 significantly reduced the levels ofon the dental surfaces of rats by more than 2 orders of magnitude of the levels in the dental caries model group (p<0.05). Moreover, FB-T9 significantly reduced the caries scores (modified Keyes scoring method) in both the prevention and treatment groups (p<0.05) and had great colonization potential in the oral cavity. These results indicate the potential usefulness ofFB-T9 as a probiotic for the prevention and treatment of caries.