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Abstract Title:

Protective effect of rosmarinic acid against oxidative stress biomarkers in liver and kidney of strepotozotocin-induced diabetic rats.

Abstract Source:

J Physiol Biochem. 2015 Dec ;71(4):743-51. Epub 2015 Oct 9. PMID: 26452500

Abstract Author(s):

Nadia Mushtaq, Roberta Schmatz, Mushtaq Ahmed, Luciane Belmonte Pereira, Pauline da Costa, Karine Paula Reichert, Diéssica Dalenogare, Luana Paula Pelinson, Juliano Marchi Vieira, Naiara Stefanello, Lizielle Souza de Oliveira, Nadia Mulinacci, Maria Bellumori, Vera Maria Morsch, Maria Rosa Schetinger

Article Affiliation:

Nadia Mushtaq

Abstract:

In the present study, we investigated the efficiency of rosmarinic acid (RA) in preventing the alteration of oxidative parameters in the liver and kidney of diabetic rats induced by streptozotocin (STZ). The animals were divided into six groups (n = 8): control, ethanol, RA 10 mg/kg, diabetic, diabetic/ethanol, and diabetic/RA 10 mg/kg. After 3 weeks of treatment, we found that TBARS levels in liver and kidney were significantly increased in the diabetic/saline group and the administration of RA prevented this increase in the liver and kidney (P < 0.05). Diabetes caused a significant decrease in the activity of superoxide dismutase (SOD) and catalase (CAT) in the diabetes/saline group (P < 0.05). However, the treatment with 10 mg/kg RA (antioxidant) prevented this alteration in SOD and CAT activity in the diabetic RA group (P < 0.05). In addition, RA reverses the decrease in ascorbic acid and non-protein-thiol (NPSH) levels in diabetic rats. The treatment with RA also prevented the decrease in the Delta-aminolevulinic acid dehydratase (ALA-D) activity in the liver and kidney of diabetic rats. Furthermore, RA did not have any effect on glycemic levels. These results indicate that RA effectively reduced the oxidative stress induced by STZ, suggesting that RA is a potential candidate for the prevention and treatment of pathological conditions in diabetic models.

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