Chemical Profile, Antibacterial Activity and Antibiotic-Modulating Effect of the HexanicL. Silk Extract (Poaceae).
Antibiotics (Basel). 2019 Mar 12 ;8(1). Epub 2019 Mar 12. PMID: 30870986
Ana Beatriz Linard de Carvalho
The present study aimed to determine the chemical profile and to evaluate the antibacterial activity and antibiotic-modulating action of the hexanicsilk extract in association with aminoglycosides. StandardATCC 25922,ATCC 25923 andATCC 27853 strains, as well as multi-resistant27,35, and31 strains, were used in this study. Phytochemical prospection revealed the presence of the following secondary metabolites: tannins, flavones, flavonoids, and xanthones, with the main chemical constituents being identified in plant extracts obtained with apolar organic solvents such as hexane. The extract presented a minimum inhibitory concentration (MIC)≥1024 μg/mL against all the tested strains. The association of the extract with aminoglycoside antibiotics showed significant synergistic effects againstand, except for amikacin, which was antagonized by the extract againstThese results indicate thesilk presents bioactive compounds with antibiotic-modulating properties. However, further research is required to characterize the effects of isolated compounds and determine their potential for drug development.