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Article Publish Status: FREE
Abstract Title:

Single oral dose toxicity test of blue honeysuckle concentrate in mice.

Abstract Source:

Toxicol Res. 2015 Mar ;31(1):61-8. PMID: 25874034

Abstract Author(s):

Hyung-Soo Kim, Sang-In Park, Seung-Hoon Choi, Chang-Hyun Song, Soo-Jin Park, Yong-Kook Shin, Chang-Hyun Han, Young Joon Lee, Sae-Kwang Ku

Article Affiliation:

Hyung-Soo Kim

Abstract:

The objective of this study was to obtain single oral dose toxicity information for concentrated and lyophilized powder of blue honeysuckle (Lonicera caerulea L., Caprifoliaceae; BHcL) in female and male ICR mice to aid in the process of developing natural origin medicinal ingredients or foods following proximate analysis and phytochemical profile measurement. The proximate analysis revealed that BHcL had an energy value of 3.80 kcal/g and contained 0.93 g/g of carbohydrate, 0.41 g/g of sugar, 0.02 g/g of protein, and 0.20 mg/g of sodium. BHcL did not contain lipids, including saturated lipids, trans fats, or cholesterols. Further, BHcL contained 4.54% of betaine, 210.63 mg/g of total phenols, 159.30 mg/g of total flavonoids, and 133.57 mg/g of total anthocyanins. Following administration of a single oral BHcL treatment, there were no treatment-related mortalities, changes in body weight (bw) or organ weight, clinical signs, necropsy or histopathological findings up to 2,000 mg/kg bw, the limited dosage for rodents of both sexes. We concluded that BHcL is a practically non-toxic material in toxicity potency.

Study Type : Animal Study

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