Abstract Title:

Involvement of p38 MAPK in the Anticancer Activity of Cultivated Cordyceps militaris.

Abstract Source:

Am J Chin Med. 2015 Jul 24:1-15. Epub 2015 Jul 24. PMID: 26205966

Abstract Author(s):

Shang-Min Chou, Wan-Jung Lai, Tzuwen Hong, Sheng-Hong Tsai, Yen-Hsun Chen, Cheng-Hsiang Kao, Richard Chu, Tang-Long Shen, Tsai-Kun Li

Article Affiliation:

Shang-Min Chou


Cordyceps militaris is a traditional Chinese medicine frequently used for tonic and therapeutic purposes. Reports from our laboratory and others have demonstrated that extracts of the cultivated fruiting bodies of C. militaris (CM) exhibit a potent cytotoxic effect against many cancer cell lines, especially human leukemia cells. Here, we further investigated the underlying mechanism through which CM is cytotoxic to cancer cells. The CM-mediated induction of PARP cleavage and its related DNA damage signal (γH2AX) was diminished by caspase inhibitor I. In contrast, a ROS scavenger failed to prevent CM-mediated leukemia cell death. Moreover, two signaling molecules, AKT and p38 MAPK, were activated during the course of apoptosis induction. Employing MTT analysis, we found that a p38 MAPK inhibitor butnot an AKT inhibitor could rescue cells from CM-mediated cell death, as well as inhibit the cleavage of PARP, formation of apoptotic bodies and up-regulation of the γH2AX signal. These results suggest that CM-mediated leukemia cell death occurs through the activation of the p38 MAPK pathway, indicating its potential therapeutic effects against human leukemia.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Apoptotic : CK(5217) : AC(3846)

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