Abstract Title:

Anti-hyperglycemic potential of Lactobacillus spp. in alloxan-induced Wistar rats.

Abstract Source:

Pak J Pharm Sci. 2017 Mar ;30(2(Suppl.)):597-600. PMID: 28650327

Abstract Author(s):

Vandana Bharti, Archana Mehta, Gajendra Kumar Mourya, Laxmi Ahirwal, Vivek K Bajpai, Shruti Shukla

Article Affiliation:

Vandana Bharti


This research was aimed to investigate anti-hyperglycemic effects of two Lactobacillus spp. on alloxan induced diabetic rats. Alloxan was administered intraperitoneally to induce the diabetic conditions in experimental rats. Animals were treated with oral administration of Lactobacillus spp., such as L. plantarum and L. acidophilus at the dose of 10(8) CFU/ml. As a result, administration of Lactobacillus spp. significantly (P<0.05) lowered blood glucose levels in diabetic rats by (201-220mg/dl) as compared to diabetic control (265mg/dl). Also, both the Lactobacillus spp. were able to reduce body weight of experimental animals as compared to control group, suggesting potent anti-hyperglycemic effect of Lactobacillus spp. in terms of their anti-diabetic potential.

Study Type : Animal Study

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