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Abstract Title:

Purification, characterization and immunomodulatory activity of a polysaccharide from Celosia cristata.

Abstract Source:

Carbohydr Polym. 2015 Nov 20 ;133:337-44. Epub 2015 Jul 8. PMID: 26344289

Abstract Author(s):

Zhenliang Sun, You Peng, Wei-Wei Zhao, Lin-Lin Xiao, Pei-Ming Yang

Article Affiliation:

Zhenliang Sun

Abstract:

A polysaccharide CP1-1 was isolated and purified from Celosia cristata. Its average molecular weight was 2.3kDa and it was composed of glucose and galactose in a ratio of 1.00:2.03, and traces of mannose. Chemical characterization of CP1-1 was elucidated by methylation analysis. CP1-1 was a branched glucogalactan which was mainly composed of 1,6-linked Galp and 1,6-linked Glcp with a ratio of 5.6:3.8. The branches were at the O-3 of the main chain and might be composed of single terminal (1→)-linked glucopyranose and galactopyranose. CP1-1 also significantly promoted the proliferation and neutral red phagocytosis of RAW 264.7 macrophage cells in vitro. In addition, CP1-1 promoted cell proliferation by enhancing the production of nitric oxide (NO), tumor necrosis factor-α (TNF-α),interleukin (IL)-6 and IL-1β. These results suggested that the polysaccharide from C. cristata could be used as a potential immunostimulator.

Study Type : In Vitro Study

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