Anti-Inflammatory and Antioxidative Potential ofon the Cartap and Malathion Mediated Toxicity in Wistar Rats.
Int J Environ Res Public Health. 2020 07 17 ;17(14). Epub 2020 Jul 17. PMID: 32709052
Vivek Kumar Gupta
has been the most useful medicinal herb in the world since ancient times due to its vast biological effects. The presence of high content of bioactive compounds makea promising complementary and alternative agent in disease prevention. The effectiveness of-based medicines against pesticide toxicity has never been evaluated. It was therefore envisaged to develop an-based strategy to protect the non-target animals from adverse effects of the pesticides. This article illustrates the ameliorating effect of aqueous extract (AE) ofleaves against the cartap and malathion toxicity. To evaluate the protective impact ofagainst cartap (Ctp), malathion (Mtn) and a mixture of both pesticides, the animals were divided in eight groups, each containing six rats: Group 1- C (control), Group 2- AE + C, Group 3- Ctp, Group 4- Mtn, Group 5- Ctp + Mtn, Group 6- AE + Ctp, Group 7- AE + Mtn, Group 8- AE + Ctp + Mtn. Wistar rats exposed to Ctp, Mtn and Ctp + Mtn, displayed significant change in body weight. It was observed that the WBC level increased significantly in Mtn and Ctp + Mtn challenged groups. The contents of TNF-α and IL-6 in serum increased expressively in the Ctp, Mtn and Ctp + Mtn challenged groups. Rats treated with Ctp, Mtn and Ctp + Mtn displayed significant alterations in the levels of antioxidative indices (MDA, GSH, GST, GPx, SOD and CAT). Significant alterations were recorded in the activities ofAST, ALT, ACP and ALP in Ctp, Mtn and Ctp + Mtn challenged groups. The histopathological results of liver supported the biochemical data. The pre-treatment of rats with the aqueous extract ofleaves significantly protected them from the toxicity of pesticides. These results suggested thatextract may be used as a promising natural agent for the management of pesticide induced toxicity.