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Article Publish Status: FREE
Abstract Title:

Thiocarbamates from Moringa oleifera Seeds Bioactive against Virulent and Multidrug-Resistant Vibrio Species.

Abstract Source:

Biomed Res Int. 2017 ;2017:7963747. Epub 2017 Jul 9. PMID: 28770224

Abstract Author(s):

Renata Albuquerque Costa, Oscarina Viana de Sousa, Ernesto Hofer, Jair Mafezoli, Francisco Geraldo Barbosa, Regine Helena Silva Dos Fernandes Vieira

Article Affiliation:

Renata Albuquerque Costa

Abstract:

Prospect of antibacterial agents may provide an alternative therapy for diseases caused by multidrug-resistant bacteria. This study aimed to evaluate the in vitro bioactivity of Moringa oleifera seed extracts against 100 vibrios isolated from the marine shrimp Litopenaeus vannamei. Ethanol extracts at low (MOS-E) and hot (MOS-ES) temperature are shown to be bioactive against 92% and 90% of the strains, respectively. The most efficient Minimum Inhibitory Concentration (MIC) levels of MOS-E and MOS-ES against a high percentage of strains were 32 µg mL(-1). Bioguided screening of bioactive compounds showed that the ethyl acetate fraction from both extracts was the only one that showed antibacterial activity. Vibriocidal substances, niazirine and niazimicine, were isolated from the aforementioned fraction through chromatographic fractionation.

Study Type : In Vitro Study

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