Abstract Title:

Protective effects of thymol on LPS-induced acute lung injury in mice.

Abstract Source:

Microb Pathog. 2017 Dec 25 ;116:8-12. Epub 2017 Dec 25. PMID: 29284133

Abstract Author(s):

Lan Yao, Guo Hou, Lu Wang, Xiao-Shu Zuo, Zhou Liu

Article Affiliation:

Lan Yao


Thymol, a naturally occurring phenol isolated from thyme, has been known to exhibit anti-inflammatory and anti-oxidative effects. The aim of this study was to determine the effect of thymol on acute lung injury (ALI) within an lipopolysaccharide (LPS)-induced mouse model. ELISA and western blotting were performed to detect the pro-inflammatory cytokines and signaling pathways. The myeloperoxidase (MPO) activity and MDA content in lung tissues, lung wet/dry (W/D) ratio and histopathological examination were detected. The results showed that thymol inhibit LPS-induced TNF-α, IL-6 and IL-1β production in BALF. Furthermore, thymol significantly reduced the MPO activity, MDA content, lung wet/dry weight ratio and histopathological changes induced by LPS. In addition, thymol inhibited LPS-induced NF-κB signaling pathway and up-regulated the expression of Nrf2 and HO-1. In conclusion, we found that thymol had anti-inflammatory and anti-oxidative effects against LPS-induced ALI and the mechanism was through suppressed NF-κB signaling pathway and activating Nrf2 signaling pathway.

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Sayer Ji
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