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Abstract Title:

Thymoquinone attenuates IgE-mediated allergic response via pi3k-Akt-NFκB pathway and upregulation of the Nrf2-HO1 axis.

Abstract Source:

J Food Biochem. 2020 Mar 24:e13216. Epub 2020 Mar 24. PMID: 32212163

Abstract Author(s):

Ayed Dera, Prasanna Rajagopalan, Irfan Ahmed, Mohammad Alfhili, Jawaher Alsughayyir, Harish C Chandramoorthy

Article Affiliation:

Ayed Dera

Abstract:

IgE-dependent reactions mediate the majority of allergic diseases. This study explores the effects of thymoquinone (Tq) on IgE-mediated allergic response in activated mast cells, basophils, and neutrophils. Tq treatment resulted in a dose-dependent decrease in levels of TNF-α and IL-4 in activated RBL-2H3 cells. Tq inhibited the degranulation of these cells with an ICvalue of 56.37 µM. Moreover, the compound suppressed basophil activation induced through FcεRI receptors with an ICvalue of 45.76 µM in heparinized human whole blood. Likewise, neutrophil migration and elastase activity were dose-dependently reduced. While Tq decreased the phosphorylation of Akt and NFκB in activated RBL-2H3 cells, it increased nuclear Nrf2 and HO-1 antioxidant proteins. Our results indicate that Tq possesses demonstrable activity in cellular models of IgE-mediated allergic reactions. PRACTICAL APPLICATIONS: The current study sheds light on the mechanistic pathways of Tq on IgE-based response in activated mast cells, basophils, and neutrophils. The output of this preclinical in vitro study may be translated into better chemotherapeutic applications of Tq and its analogs in the treatment of allergic inflammation. However, a detailed investigation of in vivo models is recommended.

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