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Abstract Title:

Thymoquinone attenuates lead-induced nephropathy in rats.

Abstract Source:

J Biochem Mol Toxicol. 2018 Oct 5:e22238. Epub 2018 Oct 5. PMID: 30290066

Abstract Author(s):

Aymen Mabrouk

Article Affiliation:

Aymen Mabrouk

Abstract:

Kidney hazards from lead (Pb) exposure are one of the fastest growing areas of concern in toxicology today. The thymoquinone (TQ) renoprotective effect against Pb-induced nephropathy has not previously been studied. Therefore, adult male Wistar rats were treated with Pb (2000 ppm of Pb acetate in drinking water) and/or TQ (5 mg/kg/day,  per os). All treatments were applied for 5 weeks. The results indicated that Pb exposure produced metal deposition, histopathological changes, functional impairment (significant elevation in plasma urea, uric acid, and creatininelevels), total antioxidant status decrease, and lipid peroxidation stimulation in the kidneys. Interestingly, TQ supplementation remarkably improved the Pb-induced renal adverse effects without significantly reducing the tissue metal accumulation. In conclusion, our data indicate for the first timea protective effect of TQ against Pb-induced nephropathy, most likely through an antioxidant mechanism. On this basis, TQ deserves more consideration and further examination as a potential therapeutic option.

Study Type : Animal Study

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Sayer Ji
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