Abstract Title:

Cardioprotective effect of Thymoquinone: A constituent of Nigella sativa L., against myocardial ischemia/reperfusion injury and ventricular arrhythmias in anaesthetized rats.

Abstract Source:

Pak J Pharm Sci. 2015 Jul ;28(4):1267-73. PMID: 26142517

Abstract Author(s):

Ersöz Gonca, Çağla Kurt

Article Affiliation:

Ersöz Gonca

Abstract:

Reperfusion of the ischemic myocardium causes the myocardial injury and life-threatening ventricular arrhythmias in human. This study aimed to investigate the effects of thymoquinone (TQ) on myocardial ischemia/reperfusion (I/R) injury and ischemia- and reperfusion-induced ventricular arrhythmias in anaesthetized rats. Adult male Wistar albino rats were divided into two groups, each containing a control and TQ-treated subgroups. In group I, the myocardial infarct size was determined by triphenyl tetrazolium chloride staining following 2-h reperfusion preceded by 30 min of ischemia. In group II, a 6-min myocardial ischemia was followed by a 10-min reperfusion. TQ-treated subgroups were treated with TQ (10 mg/100μl/kg, i.p.) and the control subgroups were treated with the vehicle (100 μl/kg, i.p.) 20 min prior to the ischemic period. Ischemia was induced by ligating the left main coronary artery, followed by reperfusion. TQ treatment reduced the infarct size (15±4% versus 69±6%, P<0.01). Pretreatment with TQ decreased arrhythmia scores, as well as the incidence of ventricular tachycardia and the incidence of ventricular fibrillation during the reperfusion period (arrhythmia scores: 1.4±0.3 versus 4.4±0.3, P<0.01). These results suggest that TQ confers protection against myocardial I/R injury and suppresses reperfusion-induced arrhythmias.

Study Type : Animal Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.