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Article Publish Status: FREE
Abstract Title:

Thymoquinone, as an anticancer molecule: from basic research to clinical investigation.

Abstract Source:

Oncotarget. 2017 Apr 18. Epub 2017 Apr 18. PMID: 28489566

Abstract Author(s):

Md Asaduzzaman Khan, Mousumi Tania, Shangyi Fu, Junjiang Fu

Article Affiliation:

Md Asaduzzaman Khan

Abstract:

Thymoquinone is an anticancer phytochemical commonly found in black cumin. In this review, we discuss the potential of thymoquinone as anticancer molecule, its mechanism of action and future usage in clinical applications. Thymoquinone exhibits anticancer activity via numerous mechanisms of action, specifically by showing selective antioxidant and oxidant activity, interfering with DNA structure, affecting carcinogenic signaling molecules/pathways and immunomodulation. In vitro activity of thymoquinone has been further implicated in animal models of cancer; however, no clinical application has been proven yet. This is the optimum time to focus on clinical trials for developing thymoquinone as a future drug in cancer therapeutics.

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