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Article Publish Status: FREE
Abstract Title:

Evaluation of the in vitro and in vivo inhibitory effect of thymoquinone on piroplasm parasites.

Abstract Source:

Parasit Vectors. 2019 Jan 16 ;12(1):37. Epub 2019 Jan 16. PMID: 30651142

Abstract Author(s):

Shimaa Abd El-Salam El-Sayed, Mohamed Abdo Rizk, Naoaki Yokoyama, Ikuo Igarashi

Article Affiliation:

Shimaa Abd El-Salam El-Sayed

Abstract:

BACKGROUND: Developing new antibabesial drugs with a low toxic effect to the animal and with no resistance from Babesia parasites is in urgent demand. In this concern, the antimalarial, anticancer and antioxidant effect of thymoquinone (TQ), a phytochemical compound found in the plant Nigella sativa, has been reported. Therefore, in the present study, the antibabesial effect of this compound was evaluated on the growth of piroplasm parasites.

RESULTS: Significant inhibition (P<0.05) of the in vitro growth of piroplasm parasites were observed after treatment by TQ with ICvalues of 35.41± 3.60, 7.35 ± 0.17, 0.28 ± 0.016, 74.05 ± 4.55 and 67.33 ± 0.94 μM for Babesia bovis, Babesia bigemina, Babesia divergens, Theileria equi and Babesia caballi, respectively. The in vitro inhibitory effect of TQ was significantly enhanced (P<0.05) when used in combination with either diminazene aceturate on bovine Babesia and equine Babesia and Theileria cultures. In B. microti-infected mice, oral and intraperitoneal administrations of TQ showed significant (P<0.05) inhibition of parasite growth at a dose of 70 mg/kg and 50 mg/kg, respectively, compared to the control group.

CONCLUSIONS: The obtained results indicate that thymoquinone might be a promising medicinal compound for use in the treatment of animal piroplasmosis.

Study Type : Animal Study, In Vitro Study

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