Abstract Title:

: A review of its immunomodulatory properties.

Abstract Source:

J Diet Suppl. 2021 Jan 22:1-15. Epub 2021 Jan 22. PMID: 33480818

Abstract Author(s):

Charles R Yates, Eugene J Bruno, Mary E D Yates

Article Affiliation:

Charles R Yates


Emergent health threats have heightened human awareness of the need for health and wellness measures that promote resilience to disease. In addition to proper nutrition and exercise, health-conscious consumers are seeking natural-based modalities,botanical preparations, that positively impact the immune system. In Ayurvedic ethnomedicine,), a deciduous climbing shrub indigenous to India, has been used to historically to combat acute and chronic inflammation as well as to promote a balanced immune response. As a dietary supplement,has been administered most often as a decoction either alone or in compositions containing other medicinal plant extracts of theandspecies. Extensive phytochemical characterization of aqueous and alcoholic extracts of differentspecies has identified over two hundred different phytochemicals from non-overlapping chemical classes with the most abundant being diterpenoids containing the clerodane-type skeleton. Numerous pharmacology studies have demonstrated thatmodulates key signaling pathways related to cell proliferation, inflammation, and immunomodulation. However, rigorous dereplication studies to identify active constituents in variousextracts and their fractions are lacking. In this review, we will summarize the current information regarding's ethnomedicinal uses, phytochemistry, pharmacological activities, and safety in order to highlight its potential as an immunomodulatory dietary supplement.

Study Type : Review
Additional Links
Pharmacological Actions : Immunomodulatory : CK(4048) : AC(1475)

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.