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Abstract Title:

: A review of its immunomodulatory properties.

Abstract Source:

J Diet Suppl. 2021 Jan 22:1-15. Epub 2021 Jan 22. PMID: 33480818

Abstract Author(s):

Charles R Yates, Eugene J Bruno, Mary E D Yates

Article Affiliation:

Charles R Yates

Abstract:

Emergent health threats have heightened human awareness of the need for health and wellness measures that promote resilience to disease. In addition to proper nutrition and exercise, health-conscious consumers are seeking natural-based modalities,botanical preparations, that positively impact the immune system. In Ayurvedic ethnomedicine,), a deciduous climbing shrub indigenous to India, has been used to historically to combat acute and chronic inflammation as well as to promote a balanced immune response. As a dietary supplement,has been administered most often as a decoction either alone or in compositions containing other medicinal plant extracts of theandspecies. Extensive phytochemical characterization of aqueous and alcoholic extracts of differentspecies has identified over two hundred different phytochemicals from non-overlapping chemical classes with the most abundant being diterpenoids containing the clerodane-type skeleton. Numerous pharmacology studies have demonstrated thatmodulates key signaling pathways related to cell proliferation, inflammation, and immunomodulation. However, rigorous dereplication studies to identify active constituents in variousextracts and their fractions are lacking. In this review, we will summarize the current information regarding's ethnomedicinal uses, phytochemistry, pharmacological activities, and safety in order to highlight its potential as an immunomodulatory dietary supplement.

Study Type : Review
Additional Links
Pharmacological Actions : Immunomodulatory : CK(4048) : AC(1475)

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