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Article Publish Status: FREE
Abstract Title:

Tobacco use increases susceptibility to bacterial infection.

Abstract Source:

Tob Induc Dis. 2008 Dec 18 ;4:12. Epub 2008 Dec 18. PMID: 19094204

Abstract Author(s):

Juhi Bagaitkar, Donald R Demuth, David A Scott

Article Affiliation:

Juhi Bagaitkar

Abstract:

Active smokers and those exposed to secondhand smoke are at increased risk of bacterial infection. Tobacco smoke exposure increases susceptibility to respiratory tract infections, including tuberculosis, pneumonia and Legionnaires disease; bacterial vaginosis and sexually transmitted diseases, such as chlamydia and gonorrhoea; Helicobacter pylori infection; periodontitis; meningitis; otitis media; and post-surgical and nosocomial infections. Tobacco smoke compromises the anti-bacterial function of leukocytes, including neutrophils, monocytes, T cells and B cells, providing a mechanistic explanation for increased infection risk. Further epidemiological, clinical and mechanistic research into this important area is warranted.

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