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Abstract Title:

A novel cosmetic antifungal/anti-inflammatory topical gel for the treatment of mild to moderate seborrheic dermatitis of the face: a open-label trial utilizing clinical evaluation and erythemadirected digital photography.

Abstract Source:

G Ital Dermatol Venereol. 2017 Jan 24. Epub 2017 Jan 24. PMID: 28121079

Abstract Author(s):

Federica Dall'oglio, Aurora Tedeschi, Carmelinda M Fusto, Francesco Lacarrubba, Franco Dinotta, Giuseppe Micali

Article Affiliation:

Federica Dall'oglio

Abstract:

BAKGROUND: Topical cosmetic agents may play a role in the management of facial seborrheic dermatitis by reducing inflammation and scale production. Advanced digital photography, equipped with technology able to provide a detailed evaluation of red skin components corresponding to vascular flare (erythema-directed digital photography), is a useful tool for evaluation of erythema in patients affected by inflammatory dermatoses. The aim of this study was to assess the efficacy and safety of a new cosmetic topical gel containing ciclopiroxolamine, lactoferrin, glycero-phosphoinositol (GPI) and Aloe vera, for the treatment of facial seborrheic dermatitis by clinical and advanced digital photography evaluation.

METHODS: An open-label, prospective, clinical trial was conducted on 25 patients with mild to moderate facial seborrheic dermatitis. Subjects were instructed to apply the gel twice daily for 45 days. The clinical efficacy was evaluated by measuring at baseline, at day 15 and 45 the degree of desquamation (by clinical examination) and erythema (by digital photography technology via VISIACRTM system equipped with RBX™), using a 5-point severity scale, and pruritus (by subject completed Visual Analogue Scale; scale from 0 to 100 mm). Finally, at baseline and at the end of the study IGA (Investigator Global Assessment) was performed using a 5-point severity scale (from 0 =worsening to 4= excellent response).

RESULTS: At the end of treatment, a significant reduction (p<0.001) of all considered parameterswas observed. Moreover, an excellent response (>80% improvement) was recorded in 47.9% of patients, with no case of worsening. No signs of local intolerance were documented.

CONCLUSIONS: The tested cosmetic topical gel was effective in treating mild to moderate seborrheic dermatitisof the face. Erythema-directed digital photography may represent a noteworthy tool for the therapeutic monitoring of facial seborrheic dermatitisand an important adjunct aid in the dermatologic clinical practice.

Study Type : Human Study

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Sayer Ji
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