Total flavone of Ginkgo biloba delays cell aging by inhibiting the P16 gene expression. - GreenMedInfo Summary
[Experimental study on effect of total flavone of Ginkgo biloba on delaying cell senescence].
Zhong Yao Cai. 2009 Jan;32(1):100-2. PMID: 19445133
Department of Biology, Anhui Medical College, Hefei 230061, China. [email protected]
OBJECTIVE: To investigate the mechanism of delaying the senescence of human diploid fibroblast (2BS) by total flavone of Ginkgo biloba (FG).
METHODS: The drug sera of FG was used to treat the 2BS. The population doublings of 2BS cells were observed, the mRNA expression of P16 gene was determined by fluorescence real-time quantitative PCR.
RESULTS: FG significantly extended the population doublings of 2BS cells, and decreased the expression of P16 mRNA.
CONCLUSION: FG can delay the senescence of cells by inhibiting the P16 gene expression.