Abstract Title:

Total glucosides of peony attenuates experimental autoimmune encephalomyelitis in C57BL/6 mice.

Abstract Source:

J Neuroimmunol. 2015 Jul 15 ;284:67-73. Epub 2015 May 12. PMID: 26025060

Abstract Author(s):

Qiling Huang, Xiaomeng Ma, Dong Liang Zhu, Li Chen, Ying Jiang, Linli Zhou, Lei Cen, Rongbiao Pi, Xiaohong Chen

Article Affiliation:

Qiling Huang

Abstract:

Total glucosides of peony (TGP), an active compound extracted from the roots of Paeonia lactiflora Pall, has wide pharmacological effects on nervous system. Here we examined the effects of TGP on experimental autoimmune encephalomyelitis (EAE), an established model of multiple sclerosis (MS). The results showed that TGP can reduce the severity and progression of EAE in C57 BL/6 mice. In addition, TGP also down-regulated the Th1/Th17 inflammatory response and prevented the reduced expression of brain-derived neurotrophic factor and 2',3'-cyclic nucleotide 3'-phosphodiesterase of EAE. These findings suggest that TGP could be a potential therapeutic agent for MS.

Study Type : Animal Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.