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Abstract Title:

[Experimental study of saponins from Tribulus terrestris on renal carcinoma cell line].

Abstract Source:

Zhongguo Zhong Yao Za Zhi. 2005 Aug;30(16):1271-4. PMID: 16245908

Abstract Author(s):

Huang-jian Yang, Wei-jing Qu, Bin Sun

Abstract:

OBJECTIVE: To investigate the effect of saponins from Tribulus terrestris (STT) on the renal carcinoma cell (786-0) in vitro, and inhibitory mechanisms. METHOD: Effects of SIT on the cytotoxicity, morphological changes of apoptosis, cell cycle and expression of Bcl-2 protein in the 786-0 were tested respectively by MTT method, Wright and acridine orange stain assay, as well as flow cytometry (FCM). RESULT: After the 786-0 was treated by STY, it was shown that: 1) A significant cytotoxic effect was observed by MTT assay; 2) Apoptosis-induced was viewed by Wright and acridine orange stain assay; 3) The distribution of 786-0 on S phase was increased; 4.) The expression of Bcl-2 protein and cyclin D1 was decreased. CONCLUSION: STT can significantly inhibit the growth of 786-0 in vitro, partially, by apoptosis.

Study Type : In Vitro Study
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Sayer Ji
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