Abstract Title:

Physiological effects and bioconcentration of triclosan on amphibian larvae.

Abstract Source:

Comp Biochem Physiol C Toxicol Pharmacol. 2010 Aug;152(2):232-40. Epub 2010 Apr 22. PMID: 20417311

Abstract Author(s):

Nicole M Palenske, Gopinath C Nallani, Edward M Dzialowski

Article Affiliation:

Department of Biological Sciences, University of North Texas, 1155 Union Circle #305220, Denton, TX 76207, USA. palensken@central.edu


We examined the acute effects of triclosan (TCS) exposure, a common antimicrobial found as a contaminant in the field, on survival and physiology of amphibian larvae. LC50 values were determined after 96h for North American larval species: Acris crepitans blanchardii, Bufo woodhousii woodhousii, Rana sphenocephala, and for a developmental model: Xenopus laevis. Amphibian larvae were most sensitive to TCS exposure during early development based upon 96-h LC50 values. Heart rates for X. laevis and North American larvae exposed to TCS were variable throughout development. Metabolic rates of X. laevis and R. sphenocephala larvae exposed to TCS were significantly affected in larvae exposed to [50% LC50] and [LC50]. Tissue uptake and tissue bioconcentration factor (BCF) of TCS were investigated in X. laevis, B. woodhousii woodhousii, and R. sphenocephala. In general, a significant increase was observed as exposure concentration increased. Tissue BCF values were dependent upon stage and species. While TCS concentrations used here are higher than environmental concentrations, exposure to TCS was dependent upon species and developmental stage, with early developmental stages being most sensitive to TCS exposure.

Study Type : Animal Study
Additional Links
Problem Substances : Triclosan : CK(157) : AC(45)
Adverse Pharmacological Actions : Cytotoxic : CK(285) : AC(125)

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