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Article Publish Status: FREE
Abstract Title:

Blocks Proliferation in Chronic Myelogenous Leukemia via the BCR-ABL/STAT5 Pathway.

Abstract Source:

Cells. 2020 Feb 6 ;9(2). Epub 2020 Feb 6. PMID: 32041350

Abstract Author(s):

Federica Sarno, Giacomo Pepe, Pasquale Termolino, Vincenzo Carafa, Crescenzo Massaro, Fabrizio Merciai, Pietro Campiglia, Angela Nebbioso, Lucia Altucci

Article Affiliation:

Federica Sarno

Abstract:

Some species of clover are reported to have beneficial effects in human diseases. However, little is known about the activity of the forage plant, or white clover, which has been recently found to exert a hepatoprotective action. Scientific interest is increasingly focused on identifying new drugs, especially natural products and their derivatives, to treat human diseases including cancer. We analyzed the anticancer effects ofin several cancer cell lines. The phytochemical components ofwere first extracted in a methanol solution and then separated into four fractions by ultra-high-performance liquid chromatography. The effects of the total extract and each fraction on cancer cell proliferation were analyzed by MTT assay and Western blotting.and, more robustly, its isoflavonoid-rich fraction showed high cytotoxic effects in chronic myelogenous leukemia (CML) K562 cells, with ICvalues of 1.67 and 0.092 mg/mL, respectively. The block of cell growth was associated with a total inhibition of BCR-ABL/STAT5 and activation of the p38 signaling pathways. In contrast, these strongly cytotoxic effects did not occur in normal cells. Our findings suggest that the development of novel compounds derived from phytochemical molecules contained inmight lead to the identification of new therapeutic agents active against CML.

Study Type : In Vitro Study

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