Abstract Title:

Triptolide induces apoptosis in human anaplastic thyroid carcinoma cells by a p53-independent but NF-kappaB-related mechanism.

Abstract Source:

Oncol Rep. 2009 Dec;22(6):1397-401. PMID: 19885592

Abstract Author(s):

Wenbo Zhu, Haiyan Hu, Pengxin Qiu, Guangmei Yan

Article Affiliation:

Department of Pharmacology, Zhong-shan School of Medicine, Sun Yat-Sen University, Guangzhou, PR China.

Abstract:

Triptolide, a traditional anti-inflammatory and anti-immunodepressive agent, has been reported to exert anti-neoplastic activity on several human tumor cell lines. This study investigates the pro-apoptotic function and the functional mechanism of triptolide on anaplastic thyroid carcinoma (ATC) cells. Experiments presented here demonstrated that triptolide had dose-dependent effects on cell viability of human ATC cell line TA-K cells through inducing cell apoptosis. In the molecular level, triptolide did not successfully initiate p53 signaling pathway, but downregulated the nuclear factor kappaB (NF-kappaB) pathway. Our studies suggest that triptolide functions as an effective apoptotic inducer in a p53-independent, but NF-kappaB-dependent mechanism, thus providing a promising agent for tumor types with p53 mutation/deletion.

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