Article Publish Status: FREE
Abstract Title:

Anticancer effect of triterpenes fromin human prostate cancer cells.

Abstract Source:

Oncol Lett. 2017 Dec ;14(6):7467-7472. Epub 2017 Oct 9. PMID: 29344190

Abstract Author(s):

Lijun Qu, Sumei Li, Yumin Zhuo, Jianfan Chen, Xiaoping Qin, Guoqing Guo

Article Affiliation:

Lijun Qu


, within the Polyporaceae family of Basidiomycota, is a popular traditional remedy medicine used in Asia to promote health and longevity. Compounds extracted fromhave revealed anticancer, antioxidant and liver protective effects.has been associated with prostate cancer cells.extracts contain numerous bioactive components; however, the exact functional monomer is unknown and the role of triterpenes from(GLT) in prostate cancer remain obscure. The present study investigated the effects of GLT on cell viability, migration, invasion and apoptosis in DU-145 human prostate cancer cells. The results demonstrated that a high dose (2 mg/ml) of GLT inhibits cell viability in a dose- and time-dependent manner by the regulation of matrix metalloproteases. Furthermore, GLT induced apoptosis of DU-145 cells. In general, GLT exerts its effect on cancer cells via numerous mechanisms and may have potential therapeutic use for the prevention and treatment of cancer.

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