Abstract Title:

Optimized Turmeric Extract Reducesβ-Amyloid and Phosphorylated Tau Protein Burden in Alzheimer's Transgenic Mice.

Abstract Source:

Curr Alzheimer Res. 2011 Aug 30. Epub 2011 Aug 30. PMID: 21875408

Abstract Author(s):

R Douglas Shytle, J Tan, P C Bickford, K Rezai-Zadeh, L Hou, J Zeng, P R Sanberg, C D Sanberg, R S Alberte, R C Fink, B Roschek

Article Affiliation:

Herbal Science Group, LLC, 1004 Collier Center Way, Suite 200, Naples FL 34110, USA. broschekhs@aol.com.


In a previous in vitro study, the standardized turmeric extract, HSS-888, showed strong inhibition of Aβ aggregation and secretion in vitro, indicating that HSS-888 might be therapeutically important. Therefore, in the present study, HSS-888 was evaluated in vivo using transgenic 'Alzheimer' mice (Tg2576) over-expressing Aβ protein. Following a six-month prevention period where mice received extract HSS-888 (5mg/mouse/day), tetrahydrocurcumin (THC) or a control through ingestion of customized animal feed pellets (0.1% w/w treatment), HSS-888 significantly reduced brain levels of soluble (~40%) and insoluble (~20%) Aβ as well as phosphorylated Tau protein (~80%). In addition, primary culturesof microglia from these mice showed increased expression of the cytokines IL-4 and IL-2. In contrast, THC treatment only weakly reduced phosphorylated Tau protein and failed to significantly alter plaque burden and cytokine expression. The findings reveal that the optimized turmeric extract HSS-888represents an important step in botanical based therapies for Alzheimer's disease by inhibiting or improving plaque burden, Tau phosphorylation, and microglial inflammation leading to neuronal toxicity.

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