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Article Publish Status: FREE
Abstract Title:

Untargeted Metabolomics Reveals Intervention Effects of Total Turmeric Extract in a Rat Model of Nonalcoholic Fatty Liver Disease.

Abstract Source:

Evid Based Complement Alternat Med. 2016 ;2016:8495953. Epub 2016 May 30. PMID: 27366193

Abstract Author(s):

Ya Wang, Ming Niu, Ge-Liu-Chang Jia, Rui-Sheng Li, Ya-Ming Zhang, Cong-En Zhang, Ya-Kun Meng, He-Rong Cui, Zhi-Jie Ma, Dong-Hui Li, Jia-Bo Wang, Xiao-He Xiao

Article Affiliation:

Ya Wang

Abstract:

Nonalcoholic fatty liver disease (NAFLD) is one of the most common forms of chronic liver disease. Currently, there are no recognized medical therapies effective for NAFLD. Previous studies have demonstrated the effects of total turmeric extract on rats with NAFLD induced by high-fat diet. In this study, serum metabolomics was employed using UHPLC-Q-TOF-MS to elucidate the underlying mechanisms of HFD-induced NAFLD and the therapeutic effects of TE. Supervised orthogonal partial least-squares-discriminant analysis was used to discover differentiating metabolites, and pathway enrichment analysis suggested that TE had powerful combined effects of regulating lipid metabolism by affecting glycerophospholipid metabolism, glycerolipid metabolism, and steroid hormone biosynthesis signaling pathways. In addition, the significant changes in glycerophospholipid metabolism proteins also indicated that glycerophospholipid metabolism might be involved in the therapeutic effect of TE on NAFLD. Our findings not only supply systematic insight into the mechanisms of NAFLD but also provide a theoretical basis for the prevention or treatment of NAFLD.

Study Type : Animal Study, In Vitro Study

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Sayer Ji
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