Abstract Title:

Ganodermasides C and D, two new anti-aging ergosterols from spores of the medicinal mushroom Ganoderma lucidum.

Abstract Source:

Biosci Biotechnol Biochem. 2011 Apr 22. Epub 2011 Apr 22. PMID: 21512225

Abstract Author(s):

Yufang Weng, Jun Lu, Lan Xiang, Akira Matsuura, Yang Zhang, Qianming Huang, Jianhua Qi

Article Affiliation:

College of Pharmaceutical Sciences, Zhejiang University.

Abstract:

Two new anti-aging compounds, ganodermasides C and D, were isolated and their structures elucidated. They are novel ergosterols possessing a 4,6,8(14),22-tetraene-3-one unit with unique hydroxylation at C-9. Both of them significantly extended the replicative lifespan of the K6001 yeast strain. Ganodermasides C and D regulated the expression of the gene for UTH1 to prolong the replicative lifespan of yeast.

Study Type : In Vitro Study
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