Two new secolignans with in vitro anti-inflammatory activities from Urtica fissa rhizomes.
J Nat Med. 2017 Jul ;71(3):553-557. Epub 2017 Feb 27. PMID: 28243817
Two new secolignans, urticin A (1) and urticin B (2), were isolated from the ethanol extract of Urtica fissa rhizomes. Their structures were elucidated on the basis of extensive spectroscopic evidence (UV, IR, HR-ESI-MS, and NMR). Urticin A and urticin B possessed in vitro anti-inflammatory activities, which significantly inhibited the TNF-α and NO release induced by LPS in RAW 264.7 cells.